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​The Melanie Avalon Podcast Episode #17 - David Sinclair

Dr. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging and how to slow its effects. More specifically, their focus is on studying sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as metabolism, neurodegeneration, cancer, cellular reprogramming, and more. 

David is the co-creator and co-chief editor of the journal Aging, has co-founded several biotechnology companies, and is an inventor on 35 patents. Among the honors and awards he’s received are his inclusion in Time Magazine’s list of the “100 Most Influential People in the World” and Time's “Top 50 in Healthcare”.

In addition, David is the author of the new book, Lifespan: Why We Age — and Why We Don’t Have To.





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The Melanie Avalon Podcast Episode #14 - Stacy Toth

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07:00 - Paleo OMAD Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group To Discuss And Learn About All Things Biohacking! All Conversations Welcome!

14:40 - David's Quest For Longevity 

17:15 - Do Yeast And Rodent Trials Apply To Humans?

19:05 - Historical Theories Of Aging

21:45 - The (Lost) Information Theory Of Aging 

22:30 - What Do Genetics And Epigenetics Look Like On A Cellular Level?

27:25 - The Piano/Pianist Gene/Epigenome Analogy 

28:45 - What Is Methylation?

30:10 - The Scratched DVD Analogy For Aging 

31:05 - Removing Damage Vs. Adding Back Informatio​n

36:20 - The Genetic Methylation Clock And Yamanaka Factors

38:10 - Restoring Vision 

44:35 - The Role Of Damage In Aging 

49:15 - Practical Implementation Of Antiaging: Fasting, Calorie Restriction, Exercise, Cold And Heat Stress

51:50 - The Role Of Sirtuins 

53:00 - Are Damaged Cells More Susceptible To Damage?  

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The Melanie Avalon Podcast Episode # 3 - Dr. Kirk Parsley

59:00 - Natural Molecules that Activate Longevity Genes

59:50 - Resveratrol From Wine Vs. Supplements 

1:01:50 - the Longest Lived People

1:02:30 - Biological Vs Mental Stress: The Importance Of Not Worrying 

1:05:10 -  IF And CR: Do You Need To Feel Hungry For Lifespan Benefits?

1:08:00 - Low Energy, Hunger, Insulin, The Mitochodria, And Longevity 

1:09:30 - The Role Of Metabolism And Thyroid 

1:12:00 - Ketones And Longevity 

The Melanie Avalon Podcast Episode #4 - Paul Saladino, MD

Can we live forever? A conversation about aging with David Sinclair PhD

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1:15:20 - NAD For Longevity, And NMN Supplementation 

1:22:10 - Fasting And Stem Cells

1:23:10 - A Thought Experiment: Living In a 200 Year Old Society 


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