The Melanie Avalon Podcast Episode #17 - David Sinclair
Dr. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging and how to slow its effects. More specifically, their focus is on studying sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as metabolism, neurodegeneration, cancer, cellular reprogramming, and more.
David is the co-creator and co-chief editor of the journal Aging, has co-founded several biotechnology companies, and is an inventor on 35 patents. Among the honors and awards he’s received are his inclusion in Time Magazine’s list of the “100 Most Influential People in the World” and Time's “Top 50 in Healthcare”.
In addition, David is the author of the new book, Lifespan: Why We Age — and Why We Don’t Have To.
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14:40 - David's Quest For Longevity
17:15 - Do Yeast And Rodent Trials Apply To Humans?
19:05 - Historical Theories Of Aging
21:45 - The (Lost) Information Theory Of Aging
22:30 - What Do Genetics And Epigenetics Look Like On A Cellular Level?
27:25 - The Piano/Pianist Gene/Epigenome Analogy
28:45 - What Is Methylation?
30:10 - The Scratched DVD Analogy For Aging
31:05 - Removing Damage Vs. Adding Back Information
36:20 - The Genetic Methylation Clock And Yamanaka Factors
38:10 - Restoring Vision
44:35 - The Role Of Damage In Aging
49:15 - Practical Implementation Of Antiaging: Fasting, Calorie Restriction, Exercise, Cold And Heat Stress
51:50 - The Role Of Sirtuins
53:00 - Are Damaged Cells More Susceptible To Damage?
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59:00 - Natural Molecules that Activate Longevity Genes
59:50 - Resveratrol From Wine Vs. Supplements
1:01:50 - the Longest Lived People
1:02:30 - Biological Vs Mental Stress: The Importance Of Not Worrying
1:05:10 - IF And CR: Do You Need To Feel Hungry For Lifespan Benefits?
1:08:00 - Low Energy, Hunger, Insulin, The Mitochodria, And Longevity
1:09:30 - The Role Of Metabolism And Thyroid
1:12:00 - Ketones And Longevity
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1:15:20 - NAD For Longevity, And NMN Supplementation
1:22:10 - Fasting And Stem Cells
1:23:10 - A Thought Experiment: Living In a 200 Year Old Society