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​The Melanie Avalon Podcast Episode #17 - David Sinclair

Dr. David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging and how to slow its effects. More specifically, their focus is on studying sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as metabolism, neurodegeneration, cancer, cellular reprogramming, and more. 

David is the co-creator and co-chief editor of the journal Aging, has co-founded several biotechnology companies, and is an inventor on 35 patents. Among the honors and awards he’s received are his inclusion in Time Magazine’s list of the “100 Most Influential People in the World” and Time's “Top 50 in Healthcare”.

In addition, David is the author of the new book, Lifespan: Why We Age — and Why We Don’t Have To.

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LEARN MORE AT​:

https://lifespanbook.com
http://instagram.com/davidsinclairphd
https://twitter.com/davidasinclair

SHOWNOTES

​

Black Friday Biohacking!!

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The Melanie Avalon Podcast Episode #14 - Stacy Toth

5:15 - JOOVV: Red Light And NIR Therapy For Fat Burning, Muscle Recovery, Mood, Sleep, And More! Use The Link melanieavalon.com/joovvFriday for $100-200 off! And Forward Your Proof Of Purchase To podcast@MelanieAvalon.com, To Receive A Signed Copy Of What When Wine: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine!

6:55 - LISTEN ON HIMALAYA!: Download The Free Himalaya App (Www.himalaya.fm) To FINALLY Keep All Your Podcasts In One Place, Follow Your Favorites, Make Playlists, Leave Comments, And More! Follow The Melanie Avalon Podcast In Himalaya For Early Access 24 Hours In Advance! You Can Also Join Melanie's Exclusive Community For Exclusive Monthly Content, Episode Discussion, And Guest Requests! Use The Code MELANIE To Get Your First Month Free!

07:00 - Paleo OMAD Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook Group To Discuss And Learn About All Things Biohacking! All Conversations Welcome!

14:40 - David's Quest For Longevity 

17:15 - Do Yeast And Rodent Trials Apply To Humans?

19:05 - Historical Theories Of Aging

21:45 - The (Lost) Information Theory Of Aging 

22:30 - What Do Genetics And Epigenetics Look Like On A Cellular Level?

27:25 - The Piano/Pianist Gene/Epigenome Analogy 

28:45 - What Is Methylation?

30:10 - The Scratched DVD Analogy For Aging 

31:05 - Removing Damage Vs. Adding Back Informatio​n

36:20 - The Genetic Methylation Clock And Yamanaka Factors

38:10 - Restoring Vision 

44:35 - The Role Of Damage In Aging 

49:15 - Practical Implementation Of Antiaging: Fasting, Calorie Restriction, Exercise, Cold And Heat Stress

51:50 - The Role Of Sirtuins 

53:00 - Are Damaged Cells More Susceptible To Damage?  

55:00 - SLEEP REMEDY: Sleep Remedy Is The Ultimate Sleep Supplement, Developed By Dr. Kirk Parlsey After Years Of Research To Naturally Restore Sleep To The Sleep-Deprived, Insomniac Navy Seals. Rather Than Knocking You Out With Drugs, Sleep Remedy Provides The Necessary Neurotransmitters And Nutrients In The Perfect Amounts To Naturally Support Your Body's Sleep Process. Use The Code MELANIEAVALON at Sleepremedy.com For 10% Off!!

The Melanie Avalon Podcast Episode # 3 - Dr. Kirk Parsley

59:00 - Natural Molecules that Activate Longevity Genes

59:50 - Resveratrol From Wine Vs. Supplements 

1:01:50 - the Longest Lived People

1:02:30 - Biological Vs Mental Stress: The Importance Of Not Worrying 

1:05:10 -  IF And CR: Do You Need To Feel Hungry For Lifespan Benefits?

1:08:00 - Low Energy, Hunger, Insulin, The Mitochodria, And Longevity 

1:09:30 - The Role Of Metabolism And Thyroid 

1:12:00 - Ketones And Longevity 

The Melanie Avalon Podcast Episode #4 - Paul Saladino, MD

Can we live forever? A conversation about aging with David Sinclair PhD

1:13:30 - DRY FARM WINES: Low Sugar, Low Alcohol, Toxin-Free, Mold- Free, Pesticide-Free, Hang-over Free Natural Wine! Use The Link DryFarmWines.com/melanieavalon To Get A Bottle For A Penny!

1:15:20 - NAD For Longevity, And NMN Supplementation 

1:22:10 - Fasting And Stem Cells

1:23:10 - A Thought Experiment: Living In a 200 Year Old Society 

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