The Melanie Avalon Biohacking Podcast Episode #262 - Dr. Nayan Patel

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)

Melanie Avalon:
friends, welcome back to the show. I am so incredibly excited about the conversation that I am about to have. So it is with a repeat guest. And when I have a repeat guest, you guys know that means I'm really, really passionate about the topic and the person. So get ready. The backstory on today's conversation, I will put a link to our first interview in the show notes, but I previously had this guest on the show, Dr. Nyan Patel, I think, man, a few years ago now, which is crazy to me. I had a mod because I read his book, The Glutathione Revolution, Fight Disease, Slow Aging, and Increase Energy. And what I was so excited about with that book is glutathione. I think it's one of the more, I would say niche supplements and that the everyday person isn't might not be super aware of glutathione, but in the health and wellness sphere in the biohacking world, everybody knows about glutathione. And I think a lot of people are supplementing glutathione. And reading that book, well, A, I learned so much about how glutathione works in the body, what it does, it's important, its purpose. And I learned all about potential issues with different supplementation routes when it comes to that because it is, like I said, a hot topic supplement in this world. And reading Dr. Patel's work, I realized there's probably just one form that I would be comfortable using to really get it into my body. And that is his oral wellness supplement. It's a transdermal glutathione. And friends, when I say I use this every single night of my life, I use this every single night of my life. I really can't imagine my life without it. I've heard so much incredible feedback from you guys as well about it. So, again, I'll put a link in the show notes to that first episode where we dive into all of that. And I'm sure we'll touch on a lot of it in today's conversation as well. But what brings us to today's conversation is A, I wanted to have him back on anyways, because like I said, I've been taking that supplement using it so regularly and noticing so many effects. So I wanted to bring him back on to hear the latest on everything. And also, we saw each other two years in a row at Dave Asprey's biohacking conference, which was so amazing. And when I saw him two conferences ago, a study had just recently come out, actually talking about COVID and the product is actually mentioned in that study, which is incredible. So I wanted to talk about that. And then the second thing is I saw him at the most recent conference and he has a skincare line utilizing glutathione. So you guys know I am all about safe, effective, incredible skincare. So we just have to have this conversation. So and he he's a fellow Trojan fight on USC. So Dr. Patel, thank you so much for being here.

Nayan Patel:
It's been my pleasure to be here. Again, it was so nice to see you again in Dallas earlier this year. One of those things that I really admire your tenacity and what you have been doing. That's why when you said that, hey, let's do this again, I said, absolutely I will do this again. So thanks for being the trooper out there and spreading the good word.

Melanie Avalon:
No, and thank you for doing what you're doing because honestly, I remember when I first saw your book, whenever somebody has a book and they have a product line associated with it, I'm always a little bit suspicious. Like, you know, I'm like, when I read this book, is it, you know, how much of it is going to be about the product and how much is going to be about the actual science? And I mean, your book is overwhelmingly, it's the science. Like, I learned so much in that book. And I really, I really do think about it and reference it all the time. Because like I said, glutathione, I mean, I'd be curious your thoughts on the commercial perspective of glutathione, but I do feel like most people, at least in the biohacking world, are pretty familiar. And I feel like there's, you know, some ballacies out there, which may be because I was revisiting our first episode and everything. And I don't want to just, you know, redo that episode right now. But could you tell listeners a little bit about, a little bit about your story as a recap and why specifically you, glutathione became an interest to you? And then what are some of the issues that you tried to address with your version of it?

Nayan Patel:
Absolutely. And you're absolutely right about the book. The book was already in writing 12 years before I even launched the product. And so I didn't have the product ready when my book was already published. And because the product was ready only for the physicians, but not for the consumers at that point. So the whole story started back in early or mid-90s when I first came out of pharmacy school. And knowing that there was nothing out there that was actually solving problems, all the medications in the world and all we were doing was managing problems. I wanted to find a solution. And when they say all roads leads to Rome, Rome in this setting was glutathione. And so my earlier research started on trying to figure out how to make glutathione. So if we make the first liposomal technology glutathione, I believe I mentioned this one in the past as well. So not to dwell on too much on that one. It did not work for my patients. So quickly I abandoned that project and moved on to a better technology, which we were able to stabilize the first form of glutathione in a water-based system in 2007. And from there onward took me, I don't know, 13, 14 years of more research, trying to figure out how much to give, how often to give, what to give it for, what kind of outcomes can I expect for my patients to experience those things. So that was a long time it took me to do that part. In the same timeframe I also started collecting data, so getting my book ready. And so the book was published and launched in 2019 and then we launched the project in 2020.

Melanie Avalon:
Just to give listeners a basic understanding of glutathione, how does it actually work in our bodies and in particular, how does it work in comparison or is it an antioxidant? What is it? Is it a protein, a molecule, an antioxidant? What is it actually doing?

Nayan Patel:
So, the glutathione is basically three amino acids coming together in one sequence, one particular sequence. That sequence is a small peptide, it's just a three amino acid chain peptide. It's not a protein because even though it's an amino acid chain, it's not considered protein, it's considered a small peptide, but it's most abundantly produced in human bodies. And the reason it gets produced most abundantly is because it does two things very effectively for us. One, you just mentioned, which is an antioxidant. It neutralizes all the free radicals in our body, and the two main free radicals, either they are oxygen-related free radicals or nitrogen-related free radicals. And these are both gases, like you breathe oxygen, your body produces nitric oxide, and when the job is done, they need to be neutralized, and excess of any of those things becomes free radicals in our body. So the glutathione actually neutralizes those two free radicals and electronically gives up an electron to kind of get itself oxidized, glutathione gets oxidized themselves, but it neutralizes the damage that's caused by free radicals. That's part one. The part two, which nobody talks about because it's very, very complex, it's all the ways it helps detoxify your body. And I mean, we know as of right now, the liver is a major organ for detoxification pathways, and there's phase one, phase two, and now phase three different pathways of detoxifying your body. Glutathione actually helps in both the phase one and two in finding those molecules, neutralizing those molecules, make them water-solubles, or help the liver kind of metabolize them further down so your body is able to easily excrete them out of the system. So that's a major function of glutathione that we don't talk about it too much, because again, the science is still learning more and more about it.

Melanie Avalon:
For the detox front, what is the role, because you talk about in the book about how glutathione is naturally recycled in the body, what is the role of how, correct me if I'm wrong, but it can be recycled with the free radical stuff, but it cannot when it is used for detox?

Nayan Patel:
Exactly. That's one of the reasons why your body has to constantly produce for the rest of your life, glutathione. If 100% gets recycled, you produce once and you're done for the rest of your life. But what happens is that when it gives up electrons, the oxidized glutathione becomes an inactive substance inside your body, and then that oxidized glutathione can actually take energy source from outside like sunlight or vitamin C or vitamin E, other so-called antioxidant, what they do is they give the energy back to glutathione to revive itself. And so that's a recycling process of glutathione. GSH is the short form of glutathione. When it gets oxidized, it becomes GS and two GS molecules come together, it becomes GSSG, which is the medical or the chemical term of this oxidized glutathione. And upon accepting electrons, it becomes GSH again. So that's a recycle process. The other process we talked about, the conjugations or the detoxification pathways of glutathione is a one-way process. In this process, glutathione gets used up because it is altering the structure of different metabolites, and in that process, glutathione gets destroyed. And so your body has to constantly produce the glutathione all the time.

Melanie Avalon:
When it gets recycled into that GSSG form and it's oxidized, does it become a pro-oxidant or is it just inert?

Nayan Patel:
It's an inert molecule. That's the best part, right? Because if you think about it, we just mentioned the term pro-oxidant. So if you think about vitamin C, everybody thinks vitamin C is an antioxidant. But chemically, vitamin C is actually a pro-oxidant. At low concentration, it's giving up its energy to revive glutathione. And so the antioxidant benefits that you experience because of taking vitamin C is not because vitamin C is an antioxidant, because what it's doing is it's reviving glutathione back and helping glutathione become a powerful source of antioxidant benefits that you experience.

Melanie Avalon:
We'll talk about, I'm sure, skincare later, but I was actually reading and interviewing Dr. Michael Greger for his book, How Not to Age. And he was talking in his book about topical skincare and vitamin C, and he was saying how it can so easily become basically a pro-oxidant, depending on what form it's in. So is it always a pro-oxidant, the vitamin C? Yes. What are the implications of that, like using it, taking it, putting it on our skin?

Nayan Patel:
Again, it's a low concentration, so it's low enough that, keep in mind, your skin is exposed to the environmental toxins the most. And so your skin has the highest amount of oxidized glutathione. So when you take topical vitamin C, it's actually reviving the glutathione under your skin much, much faster than anything, any other glutathione, there's any other oxidized glutathione inside your body. And so at the low concentration that they are, vitamin C is actually very effective in reviving this glutathione, and you can see the antioxidant benefits of glutathione immediately.

Melanie Avalon:
So when the vitamin C combines or affects the oxidized glutathione, what happens to the vitamin C? What does it turn into?

Nayan Patel:
It gets oxidized itself. An oxidized vitamin C is inert and the body just discards it.

Melanie Avalon:
Oh, so if you put vitamin C on just normal GSH, like in a test tube or a Petri dish, would nothing happen? So...

Nayan Patel:
We, so in our own formula, what we do is we have glutathione and we also have a low dose vitamin C in there. So what we do is we add a little bit of vitamin C inside of a formula so that we want to make sure that even in the process of making this glutathione, if anything gets oxidized, we want vitamin C to keep on reviving them. And so even in the pitcher dish, when you put, when you take oxidized glutathione and you put vitamin C in there, this oxidized glutathione can become glutathione, reduced form.

Melanie Avalon:
If it were just sitting by, like in the product by non-oxidized glutathione, will it just sit there until it needs to do something? Yeah, exactly.

Nayan Patel:
unless it reacts to the environmental sources that it can get oxidized as well because what is he can get oxen is pretty fast as well.

Melanie Avalon:
Okay, okay, gotcha. Yeah, I definitely want to go more into that in a little bit, the whole skincare thing. Before that, because you mentioned earlier when you were trying to make your or where you were making your glutathione supplement, making it water soluble. So that initial version that you were talking about, is that the same version that you have today with the transdermal oral supplement.

Nayan Patel:
So Melanie, you have used this product for a few years now. It has an order, it has a self order to it. It is sticky and I would say 100% of the people do not like that part.

Melanie Avalon:
I'm so used to it now though. Like I don't even, I remember when we first interviewed, when I first interviewed you, I just started using it and I was like, I was like, eh, this is going to, this is going to take some like a learning curve. Now I'm so used to it.

Nayan Patel:
We all are. We all are disappointed with those outcomes. Imagine I had this product ready in 2007 with stickiness and the order. My chemist's mind started thinking, I said, oh my God, I'm not going to put this on my body ever. But then when you see the benefit of it, then he said, okay, you know what? I'll suck it up a little bit until I see the benefits. When the benefit runs out, I'll stop it. And so all this time, all this time, 13, 14 years, I have made probably 100 different variations of this product, trying to get rid of the smell and try to get rid of the stickiness out of this whole product line. So the formula I had in 2007 when I first made it and the formula you have in your hands right now is identical. I could not even change one thing in it, not even one thing.

Melanie Avalon:
So basically that was the formula it had to be to do what it needs to do.

Nayan Patel:
Yes, and the thing is, it was like the force of nature came together and gave me this product and basically told me that, hey, this is made in nature and try to change it, but you can't, right? And so I'm not a God believer person per se, but when you believe in something so, I do believe in nature. I am a spiritual person, so I do believe in nature that, hey, everything is a purpose. And when this thing was so perfectly created, that, oh my God, I said, there is nothing I can do to change it. And the number of ingredients was so little, when I first made it, it was so little. I said, hey, how can I change ingredients in here? How can I add more things when it's, when it's something so perfect, it is very simple.

Melanie Avalon:
talking about supplements and things we put in our bodies, I am all about the, you know, original purist natural form and not, you know, I feel like so many things are just doctored and then they just, they're no pun intended, but they're like doctored up and then they just put the, like they'll like put a name on it like vitamin C, glutathione to like make it seem like it's, you know, something really helpful when really they're just trying to make something that's approachable to people that is of questionable ingredients.

Nayan Patel:
And the thing is that's unfortunate, but thanks to you and people like you that are out there edging the consumers. Because I've tried myself as a pharmacist, I talk to doctors literally every single day and educate them. And I don't talk to a lot of patients or to men, but because my focus always been, if I talk to the physicians and educate them, they'll pass on the messages to the rest of the public. But the doctors are so busy. They don't have time. And so it's people like you that are out there taking this baton and going to the consumers and educating them, which is so admirable. That's why I really admire what you are doing. Thank you.

Melanie Avalon:
No, no, thank you. I promise you when I put it on every night, I have like a moment of gratitude. I'm like, sulfur and stickiness aside, I completely have that gratitude. And it goes back to something I do want to really clarify for listeners. So, because glutathione is everywhere out there in IVs and pushes and oral supplements, when people are taking it in that form, are they getting it in their body? What effects are they getting?

Nayan Patel:
Oh wow, so that's a big question because as you can imagine, there are everybody that's out there is injecting glutathione all day long. But in the world, in all the countries in the world, nobody's ever approved glutathione for mass use. They have approved glutathione for temporary use for chemotherapy induced toxicities. And that's about it. Glutathione is a very low index of approval process and because the glutathione actually, when you inject inside your veins, it really does not get absorbed in the purest form. The body will break down the glutathione into amino acids. There is an increase of what are the amino acids inside your blood within 90 minutes, which is 16. And we are predicting, again, we do not know for sure, we are predicting that that is the reason why you still experience the benefit of glutathione about three to six hours later after you inject the product. But we do know for a fact that all the glutathione that you inject within five to 15 minutes is in your urine, you're about to pee it out. So that's the IV form, right? And so then you look at the oral form and my research basically was back in 1999 when I first picked the liposome form of glutathione and I was not getting the results I was expecting. And then in 2011, somebody did a study at the University of Texas and they took 26 kids, young kids, autistic kids, and gave them either transdermal liposome glutathione or oral liposome glutathione and they found the same exact results as the IVs where the glutathione was getting absorbed, was getting broken down, was absorbing the amino acids, and yeah, if you have no issues with conjugating those amino acids back together, your body can produce its own glutathione. And so that's what they were coming to a conclusion. Again, we do not 100% for sure know that part. So no matter what you do, something is working but not for the reasons you think it's working. And so I always look at science and science always tells us, I said, okay, whatever I do, I want predictable results. Like for example, if you have $5 and you go to a coffee shop and you put up $5 down, you rest assured that you're going to get a coffee within the $5, right? That's a predictable result. But if you said that I have money in what form I do not know and you go to a coffee shop, I say, hey, I have money, I want to show me the money first, well, right? Then they figure out how am I going to convert this into from a different currency to this currency or if I have Apple Cash or whatever, you know, people have all kinds of things. What I'm trying to give an analogy is that the glutathione, it needs to have a predictable results. And if you can remove all the uncertainties out of the equation, then we can have a better predictable results in our patient population. That's what I'm trying to do.

Melanie Avalon:
Do you know James Clement by chance? He's really great. He wrote a book called The Switch, which is about our genetic pathways for longevity. But he did a lot of research in super-centenarians and their blood work. And he has a lab and everything. And I really, really trust him on everything. I remember I was talking to him, might have been when I was reading your book. And I was like, is it true that, because he's doing lab tests all the time with all of these different things. And I was like, is it true that taking these IVs and pushes might not be having that much of an effect with the glutathione getting into our cells? And he was like, yeah, it's a complete waste of your money. He was like, don't do it. I think I had gotten sick or something. And I don't know. I was going to go get a push or an IV. And it was my first time going since reading your book. And so I was like, do I get the glutathione? Do I not? And he was like, yeah, don't get it. And I was like, OK, that's very telling. I'm curious with those ingredients that are in glutathione. So you mentioned the cysteine. And then it's also, is it glycine and glutamic acid as well?

Nayan Patel:
You know what I mean, glycine and cysteine, those are the three amino acids that comes together to make glutathione, yes. We don't put the amino acids inside because we give it the actual sequence completely intact and ready to use. Thank you.

Melanie Avalon:
Okay. Okay. Those three amino acids, if they are in the body in this, you know, prior analogy of random, vague money, but if they are, you know, all there together, is the production of glutathione substrate driven or demand driven?

Nayan Patel:
It's demand-driven, right? So when the demands are higher, your body will try to produce more as much as possible. But if the demand is high, but you don't have enough substrate, then your body's out of luck. And so the common thing is to just keep the substrate. That way, your body can just make it when it needs to. And that's, I mean, that's great. I would love to do that for every single thing that I need instead of, it's like what I say, right? If you teach them how to fish, then you don't have to, they'll never go hungry. But if you give them a fish, they'll go hungry tomorrow. And so if you give the body what it needs and let the body makes itself, that's the ideal way of treating the body. But you know what? As we age, the enzymes that are necessary to produce glutathione, the substrates of these things are getting less and less. And the demands are actually not getting any less. In fact, the demands are getting higher. And so if the demands are not decreasing, but our body's ability to produce glutathione is decreasing, then there's a gap on what your demand versus what your supply is. And as the gap increases to a certain point, which we don't know what that point is, there's an onset of all diseases. If you think about it, oxidative stress is what we are talking about right now, is linked to probably 80% of all diseases in the world. Some people may say it's the 100%, but I think it's fair to say at least 80% more. Nobody's gonna repeat me on that one. So if there's a possibility to reduce down the oxidative stress to bare minimum, it can never be zero because you need to have limited oxidative stress for the body to stay focused and more resilient. So all we can do is we can get it down to as low as possible. If we can reduce oxidative stress down to as low as possible, there's a potential that your body can keep on regenerating itself every so often. And you can literally have a very long, healthy life.

Melanie Avalon:
Something that blew my mind in your book, you mentioned that glutathione is, I think, our second most abundant compound or compound in the body, molecule after water. That's crazy to me. Is there any sort of feedback loop if we are providing the complete form of glutathione to our body? Will we stop producing as much?

Nayan Patel:
You ask me all the right questions, Melanie. It feels like you must be a physician out there who's doing all this work because the doctor, these are the type of questions I get from a physician normally, but then the doctor that tells them right off the bat, I said, hey, glutathione is not produced, is not dependent on a stimulus coming from the hypothalamus or the pituitary. That means the brain is not telling your body to produce glutathione, right? As oxygen stress goes up higher, the body senses the stress, produces the glutathione, neutralizes the free radicals, and you're done, right? It doesn't need any computing brain power to do that part. So that means if you take glutathione from outside sources, then what happens? What happens is that if you remember, in these three amino acids, it takes two enzymes, two ATP molecules, and one NAD molecule to produce one molecule of glutathione. Three enzymes, sorry, three amino acids, two enzymes, two ATP, and one NAD. If you give the glutathione straight up, what is it saving? Saving three amino acids. The enzymes are created based on the needs, so that's okay. You're saving two ATP, which is the energy source, and one NAD. Guess what? Your whole body is made up of building blocks from amino acids. So amino acids gets used up to make other peptides and other proteins that you need. The two ATP molecules that is saved up, guess what? Now you have more energy to do more protein synthesis in your body, to make more muscle mass, to make more proteins, whatever your body needs, right? And once that's done, guess what? You have more energy that most of the people will feel in the first 15 to 30 days. And the third thing is NAD, one of the essential molecule that is required for making any chemical reaction in your body go faster or go better. So over time, by supplying glutathione, we're not doing 100% supplementation, so it's not like that your body's ever gonna forget making the glutathione, but when we give the glutathione from outside sources, it's sparing all the building blocks, sparing energy and NAD to make your body function better. So when you supplement glutathione correctly, it's not that the glutathione itself is good for you, but the byproducts that is saving the body some energy is used up everywhere else. So that's the part that I want everybody to understand. It's like one plus one is supposed to be two, but in this case, one plus one is not just three or four, it's like five or 10.

Melanie Avalon:
And that actually speaks as well to, because like I said, when I saw you two conferences ago, the study, I don't know if it had published or if it was a preprint you, I remember you gave me like the actual

Nayan Patel:
Yeah, it was a preprint. It didn't get published. It didn't get published. It was preprint. It was a study on COVID. I'll let you ask me the question, but I'll tell you. It was a preprint because we were not sure if it would ever get published. A lot of journals kind of accepted it and went to the peer review process, accepted the journal article. At the very end, they said that this is a true controversial about COVID, so they were not published because they didn't want to get the heat. Oh, really? Yeah. So now it got published correctly, and then eventually, a year and a half ago, it did get published after that. Yes.

Melanie Avalon:
Okay, yeah. Oh, I was like, because I found it, like online. So, oh, yay. Awesome. I'm curious. So with that study, the researchers involved in everything, did you spearhead the study or did they come to you?

Nayan Patel:
No, they actually, the two professors at the university, so I also teach at Western University School of Pharmacy over there, and in there, they were asking me, what do I do? And so I was telling them about my research on glutathione and what I do, and he goes, oh my God. And one of the researchers, Dr. Vishwan Venkatraman, who was one of the researchers on this project as well, he has done extensive amount of research on glutathione with liposome technology. And so he goes, oh, I know glutathione. I said, okay, well, what do you know about it? I said, well, this is, it's an amazing product, but it takes about three months to kick in. Right? And he goes, oh, okay. How about I, I, I, I speed down to less than two days. And he goes, what? Right? And he goes, wow, is it possible? So, so they basically came to me at the onset of COVID in 2020, March of 2020. I said, hey, the university is shutting down. The medical center is, is, is busting through the seams. We have nothing in our arsenal to help these patients. All we can do is we give them some Tylenol, get the fever down, get some, get some steroids to help them breathe better. And if nothing fails, we put them in a ventilator so that we can keep on surviving them until we can figure out what to do with these people. And so they say that if I give glue a thiol, and if that can at least bill up your immune system, then yeah, we're not killing any viruses, but we'll let the immune system deal with it the best it can. And if it's possible, we will, we are able to keep a lot of people healthy that have an intact immune system. So that's what they did. That's exactly what they did. So I'm sorry, I'll let you ask, ask me the question.

Melanie Avalon:
No, no, no, I love it. That's amazing. I'm curious. So the version that he was talking about that took a few years, why did it take a few years for his version or the glutathione that he was talking about?

Nayan Patel:
He was using liposome technology product, and so the results that he was getting took him three to four months to get the results that he was looking for.

Melanie Avalon:
Okay, gotcha. Yeah, no, the study was so incredible. And it talks about, you know, everybody is, I think, familiar with this idea of the cytokine storm and just this overwhelming oxidative stress that people experience with COVID. And, you know, it talks all about how glutathione could be a primary role in helping to mitigate that. It doesn't name your product by name, but it talks about the potential of a glutathione. Is it cyclodextrin complex?

Nayan Patel:
Yeah, because that's my technology.

Melanie Avalon:
Yeah, with the cyclodextrin, because they do talk in that paper about the possibly potential benefits of it as well, when you chose that compound, did you anticipate it having any other benefits, or was it more about just the mechanism of getting it into the cells?

Nayan Patel:
It was just a mechanism because my goal was to stabilize glutathione. My goal was to get the glutathione particles smaller so it can cross through the barriers. My research led me, I mean, dextrin molecules, there's so many different types of dextrin molecules, cyclodextrins, cluster dextrins, there's so many different types, maltose dextrins. So I had to pick and choose, see what can I use to get my glutathione in there. So we made this proprietary blend of this product to figure out how we can, first of all, stabilize the glutathione to put a chemical cap on the sulfur molecule so you can still smell the sulfur but doesn't get oxidized. And the second part of it, if we can somehow twist the molecule without changing the polarity so that way it still, the effectors are still there but somehow squeeze the peptide into small beads. And by doing so, we can, we are able to send it through the skin into your body. So we use this molecule to basically do all that work for us. Wow, wow. In the U .S., cyclodextrin is an inactive ingredient, it has no activities, there's no medication that's been approved as an API using cyclodextrin. And so dextrin is supposed to be an inert ingredient that people use it for multiple purposes.

Melanie Avalon:
They did talk about it being potentially antiviral, but I think that was just like a vague mention.

Nayan Patel:
And that's an old, this was actually done at the NIH back in the late 80s, early 90s. NIH did some work on cyclonextrin and there's published articles out there on cyclonextrin. Actually, Dr. Fauci was involved in a couple of the researchers as well himself. Oh, wow. Yeah. And so there was a potential that cyclonextrin could have a role during viruses, but it never got materialized. It never got materialized. I don't think that the study ever passed anything like that. Again, our goal was not to use a cyclonextrin for that purpose. Our goal was to use cyclonextrin to deliver glutathione itself, which we did.

Melanie Avalon:
how stable is the product? Like does it expire? Does it?

Nayan Patel:
So oh my God, so this is, I mean, we have multiple different versions of this product, like different concentration. And as a concentration gets higher, the stability goes off the roof. The what goes off the roof? The stability of the product itself. Yeah, so like at the lower concentration, it's still good for about a couple of years. And as a concentration increases, the stability gets higher and higher. We have not done a full-blown study to exactly find the true stability data on it yet. But we are not mentioning that it's, we're telling people not to use it for, once you open the bottle, use it within three months. If you're not using the bottle, it should last you at least 18 months to two years.

Melanie Avalon:
Does it need to be refrigerated?

Nayan Patel:
Well, that's a piece of the technology that we have, that it does not require refrigeration. Now, if you put in the refrigerator, will it increase the lifespan? Absolutely it will, absolutely it will, but it does not require to be refrigerated.

Melanie Avalon:
Okay, I do keep mine in the refrigerator, but if I travel with it, and I've always wondered when I'm traveling, I'm like, Oh,

Nayan Patel:
I don't give a refrigerant, I have four bottles in my house, every bathroom has one, and downstairs in the kitchen I have one, just in case, because if my wife is cooking out there, if something gets spilled or something gets burned, it's like cure all for all her problems, I guess.

Melanie Avalon:
I love it. My favorite way to use it is if I'm going out and having a little bit more to drink than I normally would. I mean, I always use it that night, but then if I wake up in the middle of the night, I just like dowels myself with it. And I swear to not a cure for hangovers, but it's really, really amazing for helping with that.

Nayan Patel:
Well, when you drink alcohol, it depletes all your glutathione levels. And so all you're doing is replacing the glutathione levels, but if you still have some alcohol in your stomach that hasn't been digested yet, so waking up at nighttime and putting more glutathione, all you're doing is replacing your glutathione levels back to normal because it's all getting used up by alcohol.

Melanie Avalon:
That is literally my process. Like I put on before I go to bed and then I will wake up in the middle of the night and I'm like, whoop, gotta douse myself again. I haven't actually mentioned the name because I want to make sure I say it right. Is it glue?

Nayan Patel:
Glutaryl? Glutaryl. Yes. I'm so sorry. I put a scientific name to it. My brain doesn't function normally, and some people come and tell me, I said, hey, we do, we offer a service where we can name your product for you that is easy for the consumers to understand. I said, it's Glutaryl. It's a chemical name. How is that going to be? I said, oh, it's very difficult. People don't understand what Glutaryl is. I'm sorry about that.

Melanie Avalon:
That's so funny. I love it. Would you ever change the name? I'm just curious. It's too.

Nayan Patel:
late now. People are just used to that now. It's the logos are done. Everything is done. We just got trademarked. Everything is done. So I say, ah, just keep it.

Melanie Avalon:
And then there's also the plus version. What's the difference between the two?

Nayan Patel:
So the plus version was, again, in 2020, the first year when the researchers were working on the treatments for COVID, of course, it was a chaotic time. People were just drawing straws, right, trying to figure out what was the solution for anything. Anybody said something about COVID, and they flocked to it, and we'll try products more. Sure enough, when the researchers were using this product and getting positive responses in the immune responses for the patients. So they were trying a stronger version, if I could make one, for people in the hospitals, right, because we were dealing with the hospital settings. And it goes, I said, can you make something stronger? And sure enough, we made, we already had this product ready for years, but we never released the product. So we tried a few people, the doctors were very happy with the results. And long story short, a couple of people got a hold of it, and they goes, oh, my God, I only want to take this product. I said, but Glutine, I mean, more sometimes, if more may not be the best option for you, you probably want to find out what the result, how much your body needs. So anyways, we did release the product in 2021. It's a stronger version of Glutaryl. It's 1 .75 times stronger than Glutaryl itself. And it's basically used for people that have high needs of glutathione to get your body under control. And once your body's under control, they go back on the Glutaryl for maintenance purposes anyway. So they use it for three months, six months, up to a year. I have some people that have used it for about two years in a row before they can switch over to Glutaryl. And these are patients that are, I mean, these are the patients for doctors that have been working with them for years. Some people with chronic liver issues, chronic conditions, metabolic disorders that depletes your Glutine levels completely. So replacing them all the time is very critical for them. And so they use it for three months, six months, up to a year.

Melanie Avalon:
for those of us using the normal Glutaryl, when we put it on, do we actually need to physically press it into our skin? And then how long does it last?

Nayan Patel:
Yes, so the answer is yes to both. First of all, I personally also use glitter. I don't use a plus. I do use a plus when I enjoy adult beverage for sure. But normally, glitter is gonna be more than sufficient for me as well. You do have to press it in. I usually rub it in on my arms or on my belly or someplace. If you put it in your face, rubbing it in your face gets a little bit difficult, so you may want to press it in. But it takes the sheer action to kind of activate the molecule. And so when you press it in, it literally dries up in about two minutes. That's when you know it's already inside your skin. Now, it stays inside your body for anywhere from four to six hours. That's, again, according to the study that we have done at my office. We received the same study last year as well. And we found out that four to six hours is about the time it stays in the body. So if you use it twice a day, it gives you kind of eight hours, 12 hours, maybe 14 hours of coverage. And the rest of the time, the body's supposed to make some glitter time for you anyways.

Melanie Avalon:
Okay, awesome. And I will say, speaking to, you're talking about how in a few minutes it, you know, kind of disappears. It's really interesting. The intense change, it goes from how sulphury it smells to how once it goes away, you don't even smell it. So when listeners try it for the first time, have no fear, you're not going to, it's not going to smell and feel like that, like it goes away. I personally, I put it like on my chest around my collarbone area, like around my, is that an okay area? Like under my neck.

Nayan Patel:
Any non-hairy part of the body is great. People use it on the neck because if the neck is exposed to the sun, it gets damaged pretty fast.

Melanie Avalon:
Yeah, which speaking of, I'm really curious because you talk in your book about everything with the skin and glutathione, I have quite a few questions about it, just speaking to the sun damage part, you talk about how glutathione can help with skin brightening, would it make your skin more sensitive to UV damage?

Nayan Patel:
Actually, it's on the contrary because what Glutine does, it reduces the free radicals that have been created by the sun under your skin so it's supposed to, once it gets rid of the free radicals, actually your skin is not getting bombarded with this damage causing radicals, free radicals, and so in actuality, it should get your skin a chance to heal and stay healthy the whole time. So, a healthier skin is a stronger skin so it does not make you sun sensitive, in fact, let's say if you go out in the sun and if you get sunburned or you have intense amount of pain, right, of course you can buy some, if you come to my pharmacy, I'll sell you some benzocaine or lidocaine, some spray solar cane, benzocaine spray, you can spray it on so the pain goes away, but the other thing you can do is literally you can reduce those free radicals that's causing this pain by using glutathione and once you've used the free radicals, the pain goes away, when the pain goes away, so when you use glutathione, it's like a double response, right? Yes, you can help with reducing the free radicals and the free radicals is causing the pain and it's also causing the skin not to heal faster and so now all of a sudden, once you quench all the free radicals, your body is not feeling, your skin is not feeling any pain anymore and now the skin is also healing faster, so if you get sunburned, hopefully the skin is going to heal by itself much, much faster than anything else.

Melanie Avalon:
I guess the reason I was curious about that was you were talking about the role with UV stimulating is it tyrosinase and melanin and then glutathione does it inhibit that enzyme?

Nayan Patel:
Well, that's what literally supports that part, that when you block the enzymes, it can also, at a very high dosage of glutathione, it can block those enzymes, and that's how you get skin-lightening effects off it too. Keep in mind, we are using this topical product at a very low dose. We're only giving you what your body is able to produce normally, and so we're not giving you super-physiologic dosages. These are the people that were using high-dose glutathione in the IV pushers for getting skin-lightening effects. That can damage those enzymes, and it can also make your skin susceptible to sun damage.

Melanie Avalon:
I'm really just excited though by the conversation because I love when I learn the actual mechanism behind something that is very common and I never really understood how it works. So like the skin lightening or brightening, it's like what actually causes that? So like in this case, essentially what's happening is it's stopping the production of melanin that would make your skin darker.

Nayan Patel:
Yes, so the melanin stimulation comes from UV light. So if you can reduce the free radicals, then what it's doing is it reducing the potential of stimulating the melanin to produce more melanin, right? And if it deals that part, your skin, it's not like you're blocking the enzymes and you can do that too with a very high dose of a globathione, but low doses, all it's doing is it's just quenching all these free radicals, so there's no stimulation to the skin to get your skin darker. And so over time, the skin gets a little lighter or brighter. It's not because it is blocking all those enzymes and now you have another thing to worry about, but it's actually reducing the stimulation to the melanocytes to produce more melanin.

Melanie Avalon:
In your book, you talk about seven things that the skin needs. So you say vitamin C, hyaluronic acid, CoQ10, mixed tocopherols, and then you have two honorable mentions, which I don't know if I can say them, uh, cypro, esgenol, carnosine, and DMAE. So out of all of those, how much of those can we get topically versus, um, should we get via other methods?

Nayan Patel:
We have all those products in our topical creams.

Melanie Avalon:
All of those are in.

Nayan Patel:
your creams at full concentration so so beneath the technology so melody I've seen you so you have a you have a very nice face small right you don't have enough surface area to put all those ingredients on your face and enjoy the benefits of it right so what we have done we're using the technology to get all this all those ingredients reduce the particle size put them in a cream and let you have it within like one or two pumps that's it Wow

Melanie Avalon:
and they all can transport into where they need to go in the skin.

Nayan Patel:
Yes, that's our technology. So we are actually able to deliver glutathione, vitamin C, carnosine, DMA, CoQ10, resveratrol, cycloastrogenol, I mean quite a few ingredients like that as well.

Melanie Avalon:
Are they all really stable and or do they can they interact with anything?

Nayan Patel:
So they are very stable. I mean, the interaction only comes with which one is charged molecule, which one is not charged, right? So the glutathione, vitamin C, to an extent CoQ10, and very small amount of L-carnosine has a little bit of charge on it. The rest are pretty inert. So that one, the rest are okay. So with a charged molecule, we make sure that we kind of separate them out a little bit as much as possible. And so what we have done is we have created two serums with vitamin C serum and glutathione serum. So that way you get those charged molecules in the serum at a very high concentration and then use the creams to give the rest of the molecules, the rest of the ingredients to kind of go over it as well.

Melanie Avalon:
Do both the serums and the creams have all seven or do you need to do both to get all seven?

Nayan Patel:
To get all sevens, it's a four-part system. So we have two serums, one serum is for glutathione, one serum is for vitamin C, and we have two creams. The day cream, which is, well, during the daytime cream, which is the Ryzen Revive cream, has CoQ10, carnosine, DMAE, and the Rest and Repair cream, which is the nighttime, has a cyclostrogenol and the resveratrol. And I don't know if you know about resveratrol. Resveratrol is one of those ingredients that's very, very hard to stabilize and make it.

Melanie Avalon:
Resveratrol is like, you're at a, I don't know if this analogy is going to land, it's like you're at a party and Resveratrol walks in the room and everybody's like, oh, Resveratrol is here. Like the gossip starts because there's like so much controversy, I think, surrounding it, but you're a fan.

Nayan Patel:
The thing is, keep in mind, there's two things about resveratrol. One, most resveratrol chemically, when you buy the resveratrol as a chemical, has a lot of heavy metals in there. So keep in mind, the resveratrol comes from the skin of the grapes, right? That's where it's come from. And the skin has a lot of heavy metals in there. So to get the pure form of resveratrol is not very easy. It's a chemical process that the pharmaceutical company has to remove all those heavy metals out to give us the purest form of resveratrol to us. And so since we are pharmacists, we have access to high-grade ingredients. A cosmetic company normally would not have access to those high-grade ingredients.

Melanie Avalon:
Is that information on your website? I would... No. That's like a big selling point. Maybe just for me.

Nayan Patel:
It is, but the thing is, I don't want people to think that all resort rolls are bad because I don't want people to make sure... For me to look good, my product will speak for itself. I don't have to put anybody else down for me to look good, right? And so there's no point saying those kinds of things. But what I do want to say is the resort is hard to make, and it's because of this one purpose. And the second purpose is that it's very hard to dissolve in any of the chemicals. And so creating a mixture that is able to transfer through your skin is very difficult. And it took me almost two years after, even with my own research, trying to figure out, am I getting everything that I need? And it just took us so many different tweaks to get it down now. So now we have perfected the system. Now we're able to get resort roll through your skin at the recent repair cream that we have at bedtime.

Melanie Avalon:
Is there a reason you specifically chose which ingredients go in the day versus the night or why did you make those choices?

Nayan Patel:
So the daytime, I'm expecting people to go out and go in the sun, enjoy life, you know, get exposed to pollution, whatever that is. And so the daytime, I want to give you vitamin C because I want to keep on reviving this growth iron back to normal, I want to give you some co-cutin, I need some energy in your skin so that the skin looks vibrant and full of energy. Carnosine is there to keep on reviving glutathione and vitamin C. So it's like ongoing basis of making sure that there's enough antioxidant benefits that your body needs to keep on recycling glutathione and keep on quenching this free radical. Because it's like, if I give you glutathione by itself, then once it quenches all the free radicals, you're done. But if I give you vitamin C and co-cutin and cornucine, and it revives the glutathione, it quenches it, it revives them again, quenches them again, revives them again. So it's like an ongoing process. So that's my daytime process is what I've made up. The nighttime is different now. At nighttime, what I really want to do is I really want to reset anything that has happened during the daytime and repair any damage caused during the daytime. And so we use for that, we use resveratrol for that one and cycloastrogenol. Now, cycloastrogenol is a big word. Astrologers root extract is where it comes from. This thing comes from work of Dr. Elizabeth Blackburn, who won the Nobel Prize for telomeres. When she founded the telomeres is the cause of, is probably one of the longevity markers. And the research is out there that using cycloastrogenol, it actually heals and repairs the DNA and improves the telomeres. And so my focus was, I said, okay, if I want to, if I want to have a fighting chance for my skin to look better, I need all those ingredients inside. And for cycloastrogenol to work, you have to reduce oxidative stress in your skin down. So the nighttime routine includes glutathione itself as a serum and then the cream has resveratrol and the cycloastrogenol.

Melanie Avalon:
I've been testing a lot of different biological age companies. It's interesting because they'll test like all different markers and I'll get different results on different tests and it's all very confusing, but I recently tested two different companies and the one thing they both tested that I did like the best on out of everything was telomeres. I was like, that's exciting. I guess my telomeres are in good shape. So yeah, I'm so, so fascinated by the telomeres.

Nayan Patel:
Well, the telomeres increases if you can just re-sox your stress down. That's when the gluten comes into play.

Melanie Avalon:
I wish I had taken that before using glutarol versus after. I could have seen if there was a difference, but I'm not going to stop now, so too late. For these ingredients as well, the skincare, like we were talking about before, do you also press in, really press them in?

Nayan Patel:
So, the serums, yes you do. The cream is pretty easy. Creams are just, it's a passive diffusion. It goes through the lipid layers of your skin, so you just basically spread the cream around your face and that's it.

Melanie Avalon:
my audience, they know me for skincare. I talk about it all the time because I, I just think I'm really concerned. Well, so before coming to like effectiveness, I'm really concerned about problematic ingredients in skincare. And I think people are just exposing themselves to intracontrops, 24 seven through our skincare products and that it's a major, major problem. So the safety issue I'm really, really concerned about. That's why I was one of the reasons I was really, really excited to hear about what you, what you were doing with the resveratrol and then effectiveness is obviously the next thing. But so as far as your formulation, the other ingredients and safety and all of that, is there endocrine disruptors or ingredients of concern?

Nayan Patel:
So Melanie, I'm not sure if you know this thing, but I'm also a company pharmacist and my full-time job is dealing with female mostly and some male hormone replacement therapy. All I do every single day is teach doctors on how to treat the patients for hormone replacement therapy. So when it comes to endocrine system, believe me, I am all over it right now, right? I don't patients much because my focus has always been to talk to doctors. If I can help the doctors get better at prescribing these hormones, I think I'll have a good chance of spraying the word out much faster. So when it can endocrine disruptors, it is a big deal when it comes to skin care because back in the 90s, I think somebody did a study where they took a whole bunch of skin care products and they did a chemical analysis and every product had some sort of estrogen type products in there. Yeah. So what you're saying that you're adamant about this ingredients is very critical. And so when I was forming my skin care, actually I wasn't forming my skin care, I was just making it for friends and family. And then eventually this became a product now today. But for all these years, when I made for my friends and family, the idea is, can I get the purest form of ingredients that I need to make the products? And it was never going to be cost effective for the consumers to buy it. So I never made it for the consumers. Like even the vitamin C serum that I make, guess what? It's really ascorbic acid. It's not some extra form of ascorbic acid. It's tapioca base. So as you can imagine, the corn is what is the cheapest form of ascorbic acid you can buy. And it's the most abundant ascorbic acid you can buy in the United States today. And I don't buy those stuff because corn is GMO based and GMO product can actually cause, can has a potential of having endocrine disruptors for most of my patients.

Melanie Avalon:
This is excellent. This is so great. Would you consider getting EWG certification for the products? Have you thought about that?

Nayan Patel:
I'm not familiar with that part, but if it is something that needs to be done, I'm very open. It is what it is. If it's something that needs to be done, then we will definitely work on it and get it done.

Melanie Avalon:
what a lot of consumers do when they're trying to find safe products is the environmental working group. They rate skin care products, they rate household cleaning products. You can basically look up a lot of different things that you use, and then they rate every single ingredient in it, and then they give it a toxicity score of 1 to 10, I think, or 1 to 8. And so it's really helpful, because a lot of people like me, like looking for safe skin care, will go look up their products on EWG to see what number it has. And I'm assuming hearing what you're saying, I'm assuming yours would be like a 1. That'd be cool to get your products on that website, because it would be really helpful for people.

Nayan Patel:
Absolutely. Again, my job is to make products. I'm an R &D guy. If I have half an hour remaining of my day, you'll see me in the lab because I'm trying to figure out what other molecule can I make and stabilize and create some products. I understand the consumers need to trust from a third-party verification. I have a team of people that will look into that part and see if we can get it done. you

Melanie Avalon:
It's so exciting to talk to the person who actually makes the products cuz cuz only know there's this barrier wall where i'm researching the companies and i'm researching the products but i'm not actually talking to the developers so this is just this is fabulous.

Nayan Patel:
Yeah, so we make everything in-house. We control from start to finish everything. And even today's date, like today we just did a production run this morning. I was involved early in the morning to making sure that it's done correctly and the mixing was done under my supervision. And once the mixing was done, after that I left because now it's just bottling and packaging left only, that's it.

Melanie Avalon:
Ah, so, so amazing. And what studies have you conducted? You do have some studies on your website on the skincare products.

Nayan Patel:
Skin care is a little difficult because more like visible studies and how people feel with the product. Yeah, subjective. It's not more subjective studies, which is I'm not accustomed to those kind of studies. I'm more towards scientific studies, and so we can talk about that as well. But for the skin care, like, for example, the G serum that we make for the glutathione, it has clinically proven to improve wrinkles, fine lines, and skin tone in just one week. That's crazy. One week. In one week. Wow. Versus the Dr. Venkurama was telling me that some of the things that he was seeing in his studies was thinking about three-month trials before you see the data.

Melanie Avalon:
Wow, that's the vitamin C. After one week, 93% of users agreed skin felt smooth and looked clear, 85% said texture was more even, and then there's tons of, after four weeks, way more things as well.

Nayan Patel:
And this was just a four-week trial. It was a four-week study only. Of course, most of the company to ask me, say, hey, you want to do a two or three-month trial? I said, no. Nobody's gonna give it two or three months to try a product. If they don't get the results in 30 days, they're not gonna buy my product, right? I said, no, do everything in 30 days or less. And so that's what we did a 30-day trial for everything.

Melanie Avalon:
That is, that's amazing. Would you ever make an eye cream?

Nayan Patel:
We have something ready. I have not put enough attention to to kind of get it better yet, because underneath your eyes, the skin is very thin. And so my technology, if it's too sticky, it gets a little, people get a little, I mean, the skin is so thin, so they get rashes from there, right? And so I have to figure out a different way to get this ingredients inside without causing the stickiness. So instead of a serum, I may do something a little bit different to that. So I'm not sure yet. So we have something ready. So people love the product. They've already tried it. A few people have tried it. I'm Indian. So we have a lot of people with dark eye circles. And so they've used the product with some great results. But it's sticky, and the skin is so thin, so the texture is not very good yet. So I don't want to release the product yet. So I need some more time to fix it up and see if I can get better.

Melanie Avalon:
I love hearing about your process so much. Here's a question with the back to the glutathione. How much glutathione are people getting when they're using the glutarol spray versus when they're using like a glutathione skincare products? Do you get systemic effects from that or is it mostly topical?

Nayan Patel:
So the glitter is systemic effect because you are literally improving glue at iron levels. The topical version, we have more glue than in there, in fact, but we have controlled the penetration of it, so it's just to keep it skin specific. And so will they get some systemic effects? Probably. But our goal is to just help with skin benefits. So the glitter, four sprays twice a day is a typical dose, and four sprays will give you approximately 100 milligrams of glue at iron. The G serum, which is the skincare side, the serum portion, that was usually about one squirt to two squirts that they use at bedtime. Each squirt is roughly about 60 milligrams per squirt. Oh, wow. Okay. Yeah. But the thing is, the reason is because the skin has so much oxygen and stress that it just, it's barely enough to just take care of all your skin problems. Okay. Wow. So there's a lot more. If you think about it, it's more than glittery.

Melanie Avalon:
Mm-hmm, but it's it's not going in as far

Nayan Patel:
as deep because we control the stickiness is a little bit less than the glitter. But yeah, we just want to make sure we control how much it stays inside your skin because that's what it needs the most.

Melanie Avalon:
So my experience, so I won't mention the brand, but there's another brand that I work with that makes safe skincare. They actually stopped recently. It's a long story. There's a lot of drama. They're not around right now. I've been using their products for so long and I love them. And now I'm not able to replenish them because they're gone. So I'm on my last bottles. So point being, I got your products almost ideal timing and that I can use it once I finish those bottles, but I didn't want to prematurely stop those products since they're not coming back. So I gave for in the meantime, the products to my sister and I was like, I'll just buy them again. When I run out, she's obsessed. You're mentioning the one week study. She told me in a few days, she was like how much she was seeing a difference. So and I can see a difference too. And so it's been really, really incredible. And I want my other products to run out so I can switch all over and start using all of them. Oh my goodness.

Nayan Patel:
Well, thank you for sharing that part. I was going to ask you this question, say, how do you like the skincare product? Because skincare was released a long time ago, but I never, I never marketed the whole product, I never did. Really?

Melanie Avalon:
Was this out when we talked last time?

Nayan Patel:
I have skincare line forever, but I only, I give it to my wife and her friends and family, and that's all the people that bought it. Were you selling it on your website? It was on the website, but there was zero marketing behind it. I never did any studies. I didn't do anything. If packaging was old and dingy and everything was like homemade stuff, because I was, my focus was, my focus was never on skincare as much, but then realize that skincare is, is something that people spend a lot of money for. In return, they get very little value for it. And so I was very disappointed about that one. So I said, hopefully one day I can change that whole paradigm that, hey, if you pay some money, I want you to get 10 times the value of it, not one time.

Melanie Avalon:
I am so, so grateful for this. And I mean, like I said, it's good timing. So once my current products run out, I'm gonna switch over to your line. And there's a massive, massive need and market for this. Because, like I said, I've been, I've been talking about the need for safe skincare for so long. And I think there's more and more of a desire for that, especially for transparency of ingredients and everything like that. And, and that's just safe skincare is, you know, the baseline. And then on top of that, you know, we talked about how you have formulated this with, you know, what you perceive to be the seven ingredients that the skin really, really needs. And so people can get all of that in your line, which is incredible.

Nayan Patel:
at full concentration. It's just getting better ingredients at, you know, people always label that, hey, I have six ingredients inside my bottle, but like a drop of this, a drop of that doesn't, doesn't count. When I say seven ingredients, I use seven ingredients at full concentration. That means you can pick up any line. If their flagship product is just one ingredient, the full concentration of that one ingredient is in, inside my product.

Melanie Avalon:
I'm actually really curious by this. I feel like men don't, they don't flock to skincare the way women do and I'm not quite sure why. They have, they have skin as well.

Nayan Patel:
They have skin. They have skin. Yep, they do. And so, by the way, I have a man's skin care for myself personally. I've been using this for now six years.

Melanie Avalon:
Well, your skin looks great, I can say, having met you.

Nayan Patel:
So I told my staff to, hey, can you just launch this product because all my friends are getting it and they're not paying me right now because there's no price tag to put on it, right? It's a very expensive product for me to make it. And my friends goes, well, it's not on your website, so that means it's free, right? So I've been making this product, but yes, you're right. Men, so for men, I think what they need, and this is not for all men, I would say majority men, what they want is one product. They don't want a system, a layered system. They don't want it. Versus if you think about it, most females are accustomed to having a routine. And for guys, routine is you shower, you shave, you come out after shave, and that's it. You're done. And so I want to change the routine a little bit because what I want to do is give them a cream that works as an aftershave.

Melanie Avalon:
I was gonna say a clue to that, or an aftershave.

Nayan Patel:
but but it's it's it is I have actually I have done all seven ingredients into one cream now but this one is not the same as the other one because I cannot put all seven ingredients at full concentration into one and so I had to pick and choose what is the most important thing for guys so keep in mind guys skin is thicker because of testosterone their needs are going to be different than females female skin gets thinner as the age guys gets thin skin but it takes a long time for them for they get very thin skin right so thin skin wrinkles pretty fast thicker skin does not wrinkle very fast so the guys think that their skin is healthy because not wrinkling but in reality the damage the skin is the same for both male and female

Melanie Avalon:
I never knew that. That makes sense.

Nayan Patel:
We have this product ready. Again, it's not up to me. It's up to my marketing team to figure out how can they. I want all your listeners to send emails to say, when is it men's cream ready? Please let me know. They'll push them to get ready.

Melanie Avalon:
Email now.

Nayan Patel:
Email now, just say, hey, put me on a mailing list when it's ready to send me a text or email to let me know it's ready.

Melanie Avalon:
Where would they email, by the way?

Nayan Patel:
Oh, the info, the regular email, the info at oroskincare .com. That email box goes to the marketing department and they will, if they get a few increase, then they will, I think will push them. I hope they're not listening to this conversation between us.

Melanie Avalon:
I know. That's so funny. What about people with sensitive skin? Do they, will they react to any of these ingredients?

Nayan Patel:
They could, they could. I always say if there's a reaction to the skincare product, all you do is reduce the concentration down. That means if a whole squirt is what you're using, typically people use two squirts like for the full face, then go down to one squirt. If you're only using one squirt and still getting some reactions, just take a few drops of it and slowly, slowly increase it over like seven or eight days. Because what it is is basically when your body has all these free radicals, it also holds a lot of toxicities. So sensitivity comes from toxicities. So if your body is trying to basically cleanse itself from inside, it's not the product itself is bad. It's just that the body's response to it is not, it's too much too strong. And so you just reduce it down. And I can make a weaker product, but then I won't get the results. If I make too strong, then everybody will get a reaction. So I had to find a happy medium where I know for a fact, scientifically, that this is the right dosages in terms of the ingredients and the milligrams that I'm gonna give you without giving you any side effects.

Melanie Avalon:
I'm putting it out to the universe in the future. Would you ever consider making makeup?

Nayan Patel:
Oh, my God, that is not my forte at all.

Melanie Avalon:
It would just be so cool to have, like, glue-to-thigh-empowered makeup.

Nayan Patel:
And it's not my forte, I don't have an eye for color. My whole, I mean, my daughter is in color guard. So she used makeup when she is performing and things like that. But I hate her for her to put makeup on her at all. So if she's not performing or doing anything and I was like, she's completely clean skin, nothing on it. And so again, makeup is, please don't ask me to do that. Melody, I have a job to do.

Melanie Avalon:
I'm sorry. I'm just like, I'm like, it's like, I'm at Santa Claus. Like, can I have this? And can I have this?

Nayan Patel:
No, I have a job to do. I really want to focus on health and longevity space. I really want to because I probably have another 10, 15 years left to do some more research. I want to basically give you maybe one, at the most, two more ingredients that are earth shattering or life shattering. If I can do that part, by the time I'm 75, 80 years old, you know what? My job is done. I hope that somebody else can take my work and for the next generation of people to enjoy the benefits of it.

Melanie Avalon:
I mean, truly, like I said, I use that Gluterol every single night and I just have so much gratitude because you've brought this, I mean, like to recap, like we were saying earlier, the second most abundant molecule in our body that has so many crucial critical health benefits to it, and you've actually provided it in a way that people can get it into their bodies in an accessible manner, you know, at home. You don't have to go to a clinic, you don't have to go get an IV or a push, which may or may not even be, you know, getting what you, giving you what you need. And now with this skincare, there's, you know, such a need for this. So I'm so grateful and I'm excited to see the future of your work. It's really, really incredible.

Nayan Patel:
Oh, thank you. Yeah.

Melanie Avalon:
Is there anything else? Well, I will so I will share for listeners. You're so kind. We do have a discount code for listeners, which obviously I cannot recommend all of this enough. You can use the coupon code Melanie Avalon 10 that will get you 10% off all of these products that we've talked about. For that, just go to Melanie Avalon comm slash arrow. So that's a you are. Oh, and again, all the products are there and you can use the coupon code Melanie Avalon 10 to get 10% off. Like I said, I use Glutaryl every single night of my life and I'm super excited to start using the skincare. Is there anything else you wanted to share about all of this?

Nayan Patel:
Well, I wanted to share one more thing that we did last year. We did another study on glitter roll and same to professors at the university. They did another study. This time, they did a three-day study. Just for three days. Because I kind of told the guy that hey, you get the results in three months, I'll get you results in a couple of days. He goes, okay, I'll put you to the test. I'll do a three-day trial. I'll do a three-day trial. And so he did the three-day trial and what he did was he was just measuring the absorption of the glitter thion and seeing does it reduce oxidative stress down? Does it improve any immune markers? And things like that. Just want to see it out, right? So here's the results. And by the way, you can find this whole study is on the Journal of Antioxidants. It's there. It was published last year. In three days, forget three days. In four hours after one application, they saw reduction in MDA levels, which is the melanaldehyde levels, which is the markers of oxidative stress in your body. One application of four sprays reduces the dose, reduces the load for oxidative stress in your body, okay? They had to wait for three days. But when they saw that, what they did was the researchers went one step ahead. They applied the glutathione in the body. They drew the blood and put it in a test tube. They infected the blood of that blood with mycobacterium infection. And they put them in the incubator to see what happens to it. There were 30 patient trials, so 15 got glutathione, the 15 got placebo, which is nothing, right? The people that got glutathione, within one hour, they saw reduction in the mycobacterium infection in the body, in the test tube. So the research is kind of scratching the head off. I said, whoa, they were seeing these results in three months, and they're seeing this in one hour. So this is published, it's the journal of antioxidant. You can just Google glutathione, cyclodextrin, or just put glutathione and mycobacterium infection, and this study will pop up. And so I just want to let the listeners know that part, that glutathione by itself is not a drug. All it's doing, it's just basically giving the building blocks to your body. The body's doing all the work, and the body does everything for us, right? And so to see that glutathione can do this and that and other things is kind of telling me that, hey, what does a body do for you? And so I just want to make sure that people understand that, hey, look at the science, look at the research, I'm spending everything that I have on doing more trials and doing some more work so that my customers, my family members, my friends, when I talk to them, I can wholeheartedly tell them, this is what we have done, this is what we tried, this is what we worked on, why don't you give it a shot? If it doesn't work out, we do offer 100% money back guarantee.

Melanie Avalon:
Wow, that's incredible. So for listeners, we will put a link to that study in the show notes as well. And everything will be in the show notes, a full transcript and links to all of these things. And again, the code Melanie Avalon 10 for 10% off site wide at Melanie Avalon .com slash auro auro. Wow. I'm just I'm just smiling so much right now. I'm just so thank you so much, Dr. Patel for everything that you're doing. For, like I said, bringing this crucial molecule to the masses, and you're changing so many lives. And I'm just so grateful for everything, which actually speaking of the last question, I don't know if you remember this from last time, but I ask every single guest this as the very last moment on the show. What is something that you're grateful for?

Nayan Patel:
In this moment, I'm super grateful for who you are and what you're doing to spread this message out to the world. So thank you for doing that.

Melanie Avalon:
Oh, thank you so much. Well, I echo all of that back to you so, so much. And, um, oh, I can't wait. Are you going to be at the conference next year? Yes. Perfect. Well, I will definitely see you then.

Nayan Patel:
Of course. Thank you.

Melanie Avalon:
Awesome, have a beautiful rest of your day.

Nayan Patel:
Thank you. Bye-bye.